This prescription has been compounded by Physicians Preference Pharmacy on physician’s orders.


Contains micronized progesterone.

USE in women:

Treatment of Menstrual Irregularities. Protection of the Endometrium (Lining of the Uterus).

USE in men:

Relief of the symptoms of benign prostatic hyperplasia (BPH).


Bio-identical progesterone is available in many dosage forms including oral capsules, sublingual tablet, vaginal and topical preparations.  Follow dosage instructions exactly.


After the Women’s Health Initiative, a study of conjugated estrogens and medroxyprogesterone, the FDA required labeling changes for estrogen containing medications warning of the increased risk of uterine cancer, breast cancer, blood clots, heart attacks, and strokes.  This product can expose you to chemicals including  progesterone which is known to the State of California to cause cancer/birth defects or other reproductive harm (California Prop 65 Warning).


Federal law requires the provision of drug information with prescriptions.  Please note that the side effects listed in this section are for the commercially available drug Prometrium.

These side effects have been REPORTED IN STUDIES OF PROMETRIUM AT DOSES OF 100 to 400 MG/DAY: Blood and Lymphatic System: swelling of the lymph nodes Cardiovascular System: high blood pressure, hot flashes, pounding or racing of the heart Digestive System: bloating, constipation, diarrhea, dry mouth, heartburn, indigestion, nausea/vomiting General Disorders: abdominal pain (cramping), back pain, chest pain, fatigue, fever, fluid retention, headache, intestinal pain, stomach pain, swelling, swelling of the legs and arms Infections: bronchitis, fungal vaginal infection, infections, inflammation of the vagina, upper respiratory tract infection, urinary tract infection, viral infection Musculoskeletal System: arthritis, joint pain, muscle or bone pain, leg cramps, muscle cramps Nervous/Psychiatric System: anxiety, confusion, decreased concentration, depression, dizziness*, drowsiness*, irritability, mood swings, personality disorder, sleep disorder, worry. *Use caution when driving or operating heavy machinery. Respiratory System: coughing, fluid in sinus cavities, nasal congestion, sore throat, fluid in the lungs Reproductive System: breast pain, breast tenderness, vaginal discharge, vaginal  dryness, uterine fibroid Skin: acne, night sweats Eyes: blurred vision Kidney and Urinary System: urinary  problems Other adverse events: reversible cases of liver problems, particularly in patients taking high doses, rare occurrences of fainting and/or low blood pressure have also been reported. Warning signs of serious side effects: Breast lumps; pain, swelling, or tenderness in the abdomen; tremors or seizures, migraine headaches, shortness of breath or asthma; heart problems, kidney problems, abnormal vaginal bleeding, feelings of depression, pains in the calves or chest; a sudden shortness of breath; or coughing blood, indicating possible clots in the legs, heart or lungs; severe headache, vomiting, dizziness, faintness, or changes in vision or speech; weakness or numbness in an arm or leg, indicating possible clots in the brain or eye.


If you miss a dose, take it as soon as you remember, but not within 6 hours of your next dose, then resume your normal dosing schedule.  Do not “double-up” the dose.


Upon receipt, store at controlled room temperature away from sunlight and moisture.


Pink and white capsule, topical cream in a Topi Click device with pink cap or pearl Topi- Click for vaginal, white round sublingual tablet.


Contact the pharmacy for instructions on how to safely dispose of unused medication.  Do not flush unused medication or pour down sink or drain.