This prescription has been compounded by Physicians Preference Pharmacy on physician’s orders.


Contains the following bio-identical estrogens: Estradiol and Estriol.  These are identical to the hormones that are produced in the human body primarily by the ovaries.  Estrogens are responsible for the development and maintenance of the female  reproductive system, secondary sex characteristics, favorable effects on blood cholesterol and lipid profiles and slowing of the progression of osteoporosis, as well as causing excess growth of the endometrium.


Bio-identical estrogens are used for replacement therapy in peri-menopausal, menopausal, and post-menopausal women for the treatment of symptoms of low or imbalanced estrogen levels. These symptoms include vasomotor symptoms (hot flashes, night sweats) irregular menses, mood swings, and vaginal dryness.  Estrogens are also used in a variety of other conditions associated with a deficiency of estrogen hormones including female ovarian failure, or ovareotomy (removal of the ovary).  Other uses include preventing osteoporosis, ischemic heart disease and Alzheimer’s disease; improving blood lipid profile and maintaining bladder and urinary tract function.


Bio-identical estrogens are available in many dosage forms including oral capsules, sublingual tablets and topical preparations.  Storage requirement depend on the dosage form used.  Please follow any special instructions from the pharmacist for your prescription. Oral preparations should be taken with a full glass of water. Sublingual tablet should be placed under the tongue. It may take some minutes to dissolve.  Follow dosage instructions exactly and be sure to consult with your physician and pharmacist for adjusting your dosage.


Adverse reactions to bio-identical hormones may be related to the dose or composition of your prescription.  Symptoms could be breast tenderness, breakthrough bleeding, nausea, fluid retention, and headaches may increase in susceptible women.The increased risk of cancer may be reduced or eliminated when used in combination with progesterone.   Please consult your physician or pharmacist if you experience any of these symptoms or have any questions.


If you miss a dose, take as soon as remembered; but not within 6 hours of your next dose, then resume your normal dosing schedule. Do not “double-up” the dose.


 Upon receipt, store at controlled room temperature away from sunlight and moisture.


Purple and white capsule;Topical Creams – Topi Click twist applicator with purple cap; Topi Click Perl with applicator for vaginal creams; Sublingual tablet- white round tablet.


Contact the pharmacy for instructions on how to safely dispose of unused medication. Do not flush unused medication or pour down sink or drain.

WARNING: After the Women’s Health Initiative. a study of conjugated estrogens and medroxy progesterone, the FDA required labeling changes for estrogen containing medications warning of the increased risk of uterine cancer, breast cancer, blood clots, heart attacks and strokes.  This product can expose you to chemicals including estrogens which are known to the State of California to cause cancer/birth defects or other reproductive harm (California Prop 65 Warning).