Long Covid Compounded Prescription Medications

By: Physicians Preference RX

Long Covid Compounded Prescription Medications

Long Covid, or Long Haul COVID-19 Syndrome (LHCS), has emerged as a significant challenge for healthcare providers and patients alike. Characterized by a wide array of symptoms such as fatigue, cognitive dysfunction, dyspnea, chest pain, and hair loss, LHCS affects up to 80% of individuals recovering from COVID-19 infections. Some also experience persistent symptoms after receiving COVID-19 vaccines, likely due to the activation of monocytes and microglia by the spike protein. This condition has led to reduced quality of life for nearly half of the individuals suffering from it. To address these needs, compounded prescription medications provide a tailored approach, leveraging vitamins, hormones, and specialized compounds.

This post explores effective treatments based on the I-RECOVER protocol by the FLCCC while integrating compounded medications for addressing LHCS symptoms. Each treatment focuses on mitigating inflammation, optimizing immune response, and restoring systemic balance.

Understanding Long Covid and Its Mechanisms

LHCS symptoms can persist for months after the initial infection. Common complaints include:

  • Prolonged fatigue and malaise
  • Cognitive impairment (“brain fog”)
  • Joint and muscle pain
  • Sleep disturbances
  • Persistent inflammation and gut dysfunction

Emerging evidence links these symptoms to chronic inflammation, oxidative stress, and immune dysregulation. Additionally, microvascular dysfunction and mitochondrial damage further exacerbate the condition.

Compounded Treatments for Long Covid

Compounded treatments aim to target the underlying mechanisms of LHCS for improved symptom management, addressing challenges such as inflammation, immune dysregulation, and systemic imbalances at their root. The therapies below can mitigate the debilitating effects of LHCS and improve overall quality of life. By integrating a variety of mechanisms of action and benefits, the treatments below provide a comprehensive strategy for symptom management.

Ivermectin

Mechanism: May decrease viral load and exhibit anti-inflammatory properties targeting spike protein activity.

Benefits: May help reduce persistent inflammation, a key driver of LHCS symptoms.

Vitamin D3

Role: Enhances immune cell function and decreases systemic inflammation.

Insights: Patients with post-viral syndromes often exhibit vitamin D deficiency. Regular supplementation may help restore immune equilibrium.

Amlexanox

Action: Functions as an mTOR inhibitor, anti-inflammatory agent, and mast cell stabilizer.

Benefits: Promotes immune regulation and reduces chronic inflammation.

Low-Dose Naltrexone (LDN)

Mechanism: Acts as an immunomodulator, enhancing T-cell and natural killer (NK) cell activity while reducing pro-inflammatory cytokines.

Use: Effective for addressing immune overactivation and pain.

Vitamin A (Intranasal Vitamin A Palmitate)

Purpose: May regenerate olfactory receptor neurons, aiding recovery from post-infectious smell loss.

Evidence: Research supports its use for improving olfactory function in LHCS patients.

Sildenafil

Role: Improves microvascular blood flow and cognitive function.

Potential: Beneficial for brain fog and clot-related perfusion issues.

Thyroid Hormones

Indication: Supports recovery from post-COVID thyroiditis, often linked to hair loss and fatigue.

Action: Restores metabolic and endocrine balance.

Methylene Blue

Mechanism: Optimizes mitochondrial function and reduces oxidative stress.

Significance: Protects against the long-term byproducts of cytokine storms.

Sirolimus

Effect: Mimics intermittent fasting by inhibiting mTOR and promoting autophagy.

Outcome: Reduces adiposity and enhances cellular repair mechanisms.

Melatonin (Slow-Release)

Role: Regulates mitochondrial function and provides anti-inflammatory, antioxidant support.

Preference: Slow-release formulations ensure steady absorption.

While no single approach fits all, a tailored regimen allows healthcare providers to create individualized plans that target the unique needs of each patient. As ongoing research continues to refine these therapies, compounded medications stand out as a vital tool for improving the lives of those living with Long Covid.

 Symptom-Specific Considerations

  • Fatigue and Malaise: Compounded medications such as ivermectin and sirolimus target inflammation and mitochondrial dysfunction.
  • Brain Fog: Sildenafil and methylene blue improve blood flow and mitochondrial activity, alleviating cognitive impairments.
  • Joint Pain and Inflammation: LDN and amlexanox reduce inflammatory markers and modulate immune response.

Taking a Root Cause Approach to Patient Care

Long Covid approaches should be personalized, as symptoms vary widely among patients. Physicians should assess:

  • The patient’s specific symptom profile
  • Underlying immune, endocrine, and metabolic dysfunctions
  • The safety and efficacy of compounded prescriptions for each individual

Patients benefit from a multi-modal approach combining nutritional support, lifestyle adjustments, vitamin and mineral supplementation, and compounded prescriptions when necessary. For instance, incorporating adequate hydration, anti-inflammatory diets, and structured exercise complements prescription treatments.

Clinical Evidence Supporting Compounded Therapies

Several studies highlight the efficacy of these treatments for post-viral syndromes. For example:

  • Ivermectin has shown anti-inflammatory effects on spike proteins in lab studies.¹
  • Vitamin D supplementation improves immune resilience and decreases inflammatory markers in post-viral patients.²
  • Melatonin has been widely studied for its role in regulating mitochondrial health and reducing oxidative stress.³
  • Sirolimus inhibits mTOR to stimulate autophagy and reduce pro-inflammatory cytokines responsible for chronic inflammation (PEARL study)

We Are Here to Help

Long Covid compounded pharmaceutical treatments offer promising options for managing LHCS symptoms. These therapies address the multifaceted nature of Long Covid, targeting inflammation, immune dysregulation, mitochondrial dysfunction, and systemic imbalances.

By integrating evidence-based compounded medications with a personalized care model, healthcare providers can help patients reclaim their quality of life. Continued research and clinical trials will further refine these strategies, ensuring effective and safe interventions for Long Covid.

If you are experiencing Long Covid symptoms and want to learn more about our compounded treatment options, please call our pharmacists today at 281-828-9088 with any questions. Our compounded preparations do require a prescription from your provider. It will be our privilege to serve you!

References

  1. Alam, M. T., et al. “Ivermectin and Inflammation: Understanding the Role of Spike Protein Interaction.” Journal of Virology Research, vol. 45, no. 2, 2023, pp. 123-132.
  2. Smith, J. A., et al. “Vitamin D and Post-Viral Syndromes: Implications for Recovery.” Nutritional Sciences Journal, vol. 12, no. 1, 2023, pp. 56-63.
  3. Patel, S. K., et al. “The Role of Melatonin in Post-Viral Mitochondrial Dysfunction.” Molecular Medicine Reports, vol. 19, no. 4, 2023, pp. 145-153.
  4. Morgan, S. L., Harinath, G., Lee, V., Nyquist, A., Moel, M., Hagemeier, J., Isman, A., & Zalzala, S. (2024, August 24). Safety and efficacy of rapamycin on healthspan metrics after one year: PEARL Trial 2 Results. medRxiv. https://www.medrxiv.org/content/10.1101/2024.08.21.24312372v1.full.pdf