Phys Pref Slim (Semaglutide) for Successful Weight Loss

Author: Ivy Garza, PharmD., R.Ph.

Phys Pref Slim (Semaglutide) for Successful Weight Loss

Are you trying to lose weight and successfully keep it off? We all know that losing weight is a challenge – often a battle that we feel we can’t win. You may be exercising and watching what you eat, but you still can’t move the numbers on the scale.

Well, we have exciting news! Did you know that we offer a new tool for weight management? It’s called Phys Pref Slim, which is a compounded sublingual form of semaglutide.

What is Semaglutide?

Semaglutide is a prescription medication used for weight loss and type 2 diabetes. This is the same active ingredient in Ozempic, Wegovy, and Rybelsus, which are injectable and oral drugs.  However, Phys Pref Slim is an innovative sublingual dosage form with fewer side effects for improved compliance and clinical results.

Benefits of Semaglutide  

  • Reduces appetite and food cravings
  • Improves insulin and glucose levels
  • Fewer side effects
  • Made as sublingual drops
  • No injections are needed

What Does Phys Pref Slim Do?

Phys Pref Slim targets the underlying causes of weight gain and metabolic syndrome. When used sublingually, typically twice weekly, along with a balanced food plan and regular physical activity, it can help you shed pounds and keep them off.

Other approaches to weight loss such as stimulants, starvation, or dietary fads may help you lose weight quickly. However, as many people know from personal experience, once you get off the program, the pounds often come back on, and then some.

The active ingredient in Phys Pref Slim, semaglutide, is classified as a glucagon-like peptide 1 (GLP-1) receptor agonist. By mimicking a hormone involved in the regulation of appetite and food intake, it reduces appetite and food cravings and helps you eat less. It has other positive effects as well. By improving insulin release, reducing the amount of glucose released by the liver, and delaying gastric emptying, it can help lower blood sugar. Semaglutide has also been shown to reduce the risk of major adverse cardiovascular events in adults with type 2 diabetes and established cardiovascular disease.

A research study demonstrated that in combination with dietary and physical activity counseling, semaglutide was well tolerated over 52 weeks and showed clinically relevant weight loss compared with placebo at all doses. (1)

Advantages of Phys Pref Slim

A significant advantage of Phys Pref Slim compared to oral and injected semaglutide products is that it has fewer side effects. If you have used Ozempic or Wegovy, you may know that side effects such as nausea, vomiting, constipation, headaches, diarrhea, and abdominal pain can be rough. Therefore, we have added BPC-157 and pyridoxine to our Phys Pref Slim formulation to reduce the associated nausea and headaches, which are common for many who use oral or injected semaglutide. Side effects observed with Phys Pref Slim typically include lightheadedness, queasiness, and slight fatigue, and they usually occur only following the first few doses. Phys Pref Slim is also hypoallergenic and free of propylene glycol, which is present in the injectable form of semaglutide.

Another advantage may be cost. Commercially available semaglutide products can cost thousands of dollars a month. We have heard from several patients that insurance, which initially covered the cost, is spontaneously ceasing coverage, leaving them in a bind. This abrupt discontinuation in coverage is both cost-prohibitive and a barrier to treatment, especially for those with type 2 diabetes who are using semaglutide to lower blood sugar.

How to Use Phys Pref Slim

Phys Pref Slim requires a prescription from your provider. It is a sublingual product, generally dosed twice weekly, as drops which are placed under the tongue. The initial low dose is gradually increased over the first month or until you reach your optimal dose. You will then continue, per your doctor’s orders, to maintain that dose until your wellness, blood sugar, and weight loss goals are achieved.

Health Benefits of Weight Loss

Besides the obvious benefit of losing those extra pounds, fitting back into your favorite clothes and looking and feeling better about yourself, weight loss has many other important benefits for your overall health. By addressing the underlying cause of your weight gain and adopting a healthy eating plan and regular exercise, your chances of losing weight increase dramatically. Even a loss of 5–10% of your total body weight (10–20 pounds for a 200-pound person) can lead to these improvements in your health:

  • Type 2 Diabetes: Your risk of developing type 2 diabetes will decline. If you already have diabetes, it will help lower your blood sugar and possibly your medication requirements.
  • Arthritis: Joint pain may improve, since every extra 10 pounds puts 40 pounds of pressure on your knees and other joints.
  • Hypertension: A loss of just 5% of your body weight can produce meaningful drops in your blood pressure.
  • Heart Disease: Triglycerides, insulin resistance, and markers of inflammation will likely fall and HDL cholesterol increase. These changes are associated with a reduced risk of heart disease.
  • Sleep Apnea: You may be able to reverse sleep apnea with sufficient weight loss and no longer require CPAP. Apnea aside, weight loss improves sleep.
  • Mood and Sense of Well-Being: You can expect a mood boost as your self-confidence, sleep, and energy improve. You may even have a boost in your sex life.

Physicians Preference Pharmacy’s High Standards

At Physicians Preference Pharmacy, our standards are more stringent than those of the United States Pharmacopeia (USP). In addition to onsite weight testing, we send multiple samples per week to an outside laboratory for potency testing. Physicians Preference Pharmacy ranks first in Houston for the number of samples sent for potency testing and in the top 8% of pharmacies nationwide. Physicians Preference Pharmacy is a Houston-based, PCAB-accredited compounding pharmacy serving physicians and patients since 2001. We are licensed to work with doctors and ship to patients in 49 states (excludes Nevada).

Get Started on Your Weight Loss Journey Today!

If you are looking for a new solution for weight management, talk to your doctor about Phys Pref Slim. For additional information, please contact the pharmacy directly at 281-828-9088. You may also visit our website at We look forward to the privilege of serving you!

Note: A prescription is required and minimum criteria must be met according to your prescriber.


  1. Efficacy and Safety of Semaglutide Compared with Liraglutide and Placebo for Weight Loss in Patients with Obesity: A Randomised, Double-Blind, Placebo and Active Controlled, Dose-Ranging, Phase 2 Trial